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KMID : 1025520040460010107
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Journal of Animal Science and Technology
2004 Volume.46 No. 1 p.107 ~ p.114
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The Effect of Beef Peptide on Blood Pressure end Serum Lipid Concentration of Spontaneously Hypertensive Rat(SHR)
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Abstract
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The purpose of this work was to examine the effect of peptide on blood pressure and serum lipid concentration of spontaneously hypertensive rat(SHR). This peptide was extracted from beef muscle hydrolysates and identified as hexapeptide, V-L-A-Q-Y-K. This peptide showed angiotensin converting enzyme(ACE) inhibition activity in vitro experimentation(IC-(50):138.34μg/㎖). Diets containing 0.2g, 0.5g, and 1.0g of the peptide per ㎏ body weight were fed to SHR every day for 8 weeks while the control group was fed on a diet and 1㎖ of drinking water instead of the peptide. Total cholesterol and LDL-cholesterol concentrations of the treatment groups were lower than those of the control diet feeding group. The significant suppression of systolic blood pressure was shown by increasing the concentration of peptide supplement, especially by 3 weeks of feeding although it started fluctuating later. These results suggest that the peptide may beneficially affect blood pressure in spontaneously hypertensive rat by the 3-week administration.
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